How comes it, that thou art then estranged from thyself?

How comes it, that thou art then estranged from thyself?

In William Shakespeare's works, the theme of self-discovery and self-awareness is a recurring motif that is explored through various characters and their journeys. One of the most famous quotes that delves into this theme is "How comes it, that thou art then estranged from thyself?" This line, spoken by the character Duke Orsino in the play "Twelfth Night", reflects the idea of being disconnected from one's true self and the struggle to find one's identity.